Massive gastric polyposis in Peutz-Jeghers Syndrome – a case report

Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder equally affecting males and females with an incidence of 1/25,000 – 1/300,000 births. It characterised by the development hamartomatous polyps digestive tract, lifetime risk colorectal cancer other gastrointestinal malignancies, as well non-gastrointestinal cancers such breast ovarian cancers. Intestinal polyposis very common in PJS, however, gastric occur less than 20% patients massive rarely reported. We report case elderly PJS patient concurrent prior intestinal multiple occurrences intussusception. The were present fundus through to gastro-eosophageal junction. Microscopy demonstrated arborising branches smooth muscle covered disorganised mucosa consistent polyps. largest polyp showed architectural complexity nuclear atypia suggestive high-grade dysplasia. An intrapolyp adenocarcinoma had been biopsied from two months but no residual invasion was gastrectomy specimen. important for pathologists be aware association between which dysplasia malignancy can develop.